The PKC/NOX/ROS and PYK2/MEK/ERK/PARP signalling pathways drive TRPM2 channel activation induced by non-cytolytic oxidative stress in microglial cells.

• Tác giả: Lin-Hua Jiang, Nur Zulaikha Mohamad Zahir, Sharifah Alawieyah Syed Mortadza, Chew Tze Wei
• Ngôn ngữ: eng
• Ký hiệu phân loại: 366.16 Nobles of the Mystic Shrine (Shriners)
• Thông tin xuất bản: England : Redox report : communications in free radical research , 2025
• Bộ sưu tập: NCBI
• ID: 746085

Tóm tắt

OBJECTIVES: The study aimed to investigate the signalling mechanism for TRPM2 channel activation by non-cytolytic oxidative stress in microglia. METHODS: Microglia from wild-type (WT) and TRPM2-knockout (KO) mice were exposed to 10-30 mM H RESULTS: Exposure of WT microglia to H CONCLUSION: Our results support that PKC/NOX-mediated ROS generation and TRPM2-mediated Ca