Development and prospective implementation of a large language model based system for early sepsis prediction.

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Tác giả: Joseph C Ahn, Eliah Aronoff-Spencer, Rishivardhan Krishnamoorthy, Sina Mohammadi, Shamim Nemati, Avi Patel, Supreeth P Shashikumar, Karandeep Singh, Gabriel Wardi

Ngôn ngữ: eng

Ký hiệu phân loại: 338.9 Economic development and growth

Thông tin xuất bản: England : NPJ digital medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 746202

Sepsis is a dysregulated host response to infection with high mortality and morbidity. Early detection and intervention have been shown to improve patient outcomes, but existing computational models relying on structured electronic health record data often miss contextual information from unstructured clinical notes. This study introduces COMPOSER-LLM, an open-source large language model (LLM) integrated with the COMPOSER model to enhance early sepsis prediction. For high-uncertainty predictions, the LLM extracts additional context to assess sepsis-mimics, improving accuracy. Evaluated on 2500 patient encounters, COMPOSER-LLM achieved a sensitivity of 72.1%, positive predictive value of 52.9%, F-1 score of 61.0%, and 0.0087 false alarms per patient hour, outperforming the standalone COMPOSER model. Prospective validation yielded similar results. Manual chart review found 62% of false positives had bacterial infections, demonstrating potential clinical utility. Our findings suggest that integrating LLMs with traditional models can enhance predictive performance by leveraging unstructured data, representing a significant advance in healthcare analytics.
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