Activity-dependent development of the body's touch receptors.

• Tác giả: Nusrat Africawala, Rabia Anjum, Jinheon Choi, David D Ginty, Annie Handler, Michael Iskols, Brendan P Lehnert, Alexandra R Magee, Michael Nolan-Tamariz, Suzanne Paradis, Sophia Renauld, Celine Santiago, Nikhil Sharma, Julianna Siegrist, Aniqa Tasnim, Josef Turecek
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.8232 Subsurface resources
• Thông tin xuất bản: United States : Neuron , 2025
• Bộ sưu tập: NCBI
• ID: 746279

Tóm tắt

We report a role for activity in the development of the primary sensory neurons that detect touch. Genetic deletion of Piezo2, the principal mechanosensitive ion channel in somatosensory neurons, caused profound changes in the formation of mechanosensory end-organ structures. Peripheral-nervous-system-specific deletion of the voltage-gated sodium channel Na