Cardiomyocyte specific CD38 deletion protects heart from acute myocardial infarction by activating Sirt3 signaling pathway.

• Tác giả: Ke-Yu Deng, Qi Ding, Xiao-Hui Guan, Mei-Xiu Jiang, Qian Li, Yi-Song Qian, Xiao-Li Tian, Ling-Fang Wang, Ke Wen, Yun-Fei Xiao, Hong-Bo Xin, Ya-Ting Zhang, Jia-Le Zhao, Qi-Hang Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 398.353 Human body, personality, qualities, activities
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 746325

Tóm tắt

Acute myocardial infarction (AMI) is serious disease with high morbidity and mortality worldwide. CD38 is an important metabolic enzyme and plays an important role in a variety of diseases. Our previous studies demonstrated that CD38 deficiency significantly reduced Ang-II-induced ventricular hypertrophy and cardiac ischemia-reperfusion injury. However, the roles of cardiomyocytic CD38 in acute myocardial infarction (AMI) remain unknown. Here, we reported that cardiomyocyte-specific CD38 deficiency (CD38