Deep vein thrombosis (DVT) remains a significant challenge in healthcare settings, with proper nursing management playing a crucial role in patient outcomes. Deep vein thrombosis (DVT) remains a significant challenge in healthcare settings, with proper nursing management playing a crucial role in patient outcomes. To assess the knowledge, attitudes, and practices (KAP) of nurses regarding deep vein thrombosis (DVT) and its nursing management. A cross-sectional survey was conducted in Zhejiang Province between August and September 2024. Data were collected using a researcher-developed questionnaire that was validated through expert consensus and pilot testing (Cronbach's α = 0.949). A total of 568 valid questionnaires were analyzed. Among the participants, 272 (47.9%) reported having experience in caring for DVT patients. The mean scores showed that 75.9% of participants achieved adequate knowledge levels, 82.5% demonstrated positive attitudes, and 83.9% exhibited proactive practices. All indicating satisfactory levels within their respective ranges. Multivariate logistic regression showed that involving in the care of DVT patients, with relative have a history of DVT, and participation in the training of DVT care were independently associated with knowledge. Concurrently, knowledge was independently associated with attitude. Moreover, knowledge and attitude were independently associated with proactive practice (All P <
0.05). Nurses demonstrated adequate knowledge, positive attitudes, and proactive practices regarding DVT and its nursing management. Targeted training programs and experiential opportunities, particularly for nurses with limited exposure to DVT care, should be prioritized to further enhance their knowledge and practices, ultimately improving patient outcomes.