Anti-inflammatory and barrier repair mechanisms of active components in Daemonorops draco Bl. for UVB-induced skin damage.

• Tác giả: Zaijun Geng, Miaomiao Guo, Jun Li, Li Li, Xiao Ling, Xingyi Wu, Fan Yi, Ying Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 364.04 Special topics of criminology
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 746472

Tóm tắt

Daemonorops draco Bl. extract and its active ingredients can remove blood stasis and promote muscle and wound healing and are widely used in skin health and other fields. Modern pharmacological studies have demonstrated that this extract exerts excellent anti-inflammatory effects beneficial for skin barrier repair. However, the mechanism of action and monomeric components of D. draco remain unclear. Seven active monomers (XJ-1 ~ XJ-7) were extracted and purified from D. draco. The successful construction of the HaCaT inflammation model was achieved through the detection of IL-1β and TNF-α expressions in UVB-irradiated HaCaT cells. Based on this cellular model, (2 S)-5-methoxy-6-methylflavan-7-ol (XJ-2) was determined to be the best-screened monomer. The effects of XJ-2 on the production of reactive oxygen species (ROS) and Ca