Single-cell transcriptomic characterization of microscopic colitis.

• Tác giả: Benjamin Y Arnold, Kristin E Burke, Daniel C Chung, Jenny Gurung, Stefan Halvorsen, Brooke Hoppe, Megan Hopton, Hamed Khalili, Yuko Kinowaki, Sidney Martin, Jessica McGoldrick, Kaia C Miller, Mari Mino-Kenudson, David Morgan, Nandini Samanta, Slim Sassi, Kyle Staller, Jessica Tantivit, Molly Thomas, Alice Tirard, Alexandra-Chloé Villani, Katherine M Williams, Joseph Yarze
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.323 Dowsing
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 746783

Tóm tắt

Microscopic colitis (MC) is a chronic inflammatory disease of the large intestine and a common cause of chronic diarrhea in older adults. Here, we use single-cell RNA sequencing analysis of colonic mucosal tissue to build a cellular and molecular model for MC. Our results show that in MC, there is a substantial expansion of tissue CD8