Turn-on fluorescent glucose transport bioprobe enables wash-free real-time monitoring of glucose uptake activity in live cells and small organisms.

• Tác giả: Monica S Hensley, David Hutchings, Aldelrahman Ismail, Marina Tanasova
• Ngôn ngữ: eng
• Ký hiệu phân loại: 355.7 Military installations
• Thông tin xuất bản: England : RSC chemical biology , 2025
• Bộ sưu tập: NCBI
• ID: 746873

Tóm tắt

The direct link between sugar uptake and metabolic diseases highlights the iminent need for molecular tools to detect and evaluate alterations in sugar uptake efficiency as approaches to identify disease-relevant metabolic alterations. However, the strict requirements of facilitative glucose transporters regarding substrate binding and translocation pose challenges for developing effective fluorescence molecular probes. Based on the state-of-the-art understanding of glucose recognition by facilitative transporters (GLUTs), we designed a glucopyranoside mimic - GluRho - that delivers the "turn-on" rhodamine B to live cells