N-acetylcysteine and raloxifene boost photodynamic therapy against cutaneous squamous cell carcinoma by decreasing TGFβ1 secreted by cancer-associated fibroblasts.

• Tác giả: Edgar Abarca-Lachen, Virginia Albiñana, Luisa María Botella, Elisa Carrasco, María Gallego-Rentero, Yolanda Gilaberte, Salvador González, Ángeles Juarranz, Marta Mascaraque, Jimena Nicolás-Morala
• Ngôn ngữ: eng
• Ký hiệu phân loại: 011.384 *Audiobooks (Talking books)
• Thông tin xuất bản: Australia : International journal of biological sciences , 2025
• Bộ sưu tập: NCBI
• ID: 746912

Tóm tắt

Cutaneous squamous cell carcinoma (cSCC) is a highly prevalent skin cancer. While surgery remains the gold standard treatment, non-invasive methods like photodynamic therapy (PDT) stand out for their high efficacy and minimal cosmetic impact. However, resistance to PDT is still a challenge. Numerous cellular processes involved in cancer biology and therapy resistance are regulated by the TGFβ1/SMAD pathway. Using