De-succinylation-induced accumulation of TRMT10C in the nucleus plays a detrimental role in coronary microembolization via its m1A modification function.

• Tác giả: Chen Chang, Ri-Xin Dai, Lei He, Chen-Kai Hu, Wan-Zhong Huang, Yan-Ling Ren, Qiang Su, Qiang Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 553.453 Tin
• Thông tin xuất bản: Australia : International journal of biological sciences , 2025
• Bộ sưu tập: NCBI
• ID: 746925
• Chủ đề: 1. De; 2. Succinylation; 3. Induced

Tóm tắt

Coronary microembolization (CME) refers to embolism in the coronary microcirculation. This study showed a reduction in succinyl transferase (CPT1A) and the succinylation substrate (succinyl-CoA) in cardiomyocytes in CME models, suppressing the succinylation of the mitochondrially localized protein TRMT10C. Suppression of succinylation promotes KPNA4 recognition of two nuclear localization signals (NLSs), KAKR and KKK(X)