Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation.

• Tác giả: Min Du, Junyi Guo, Shengqi Huo, Yue Jiang, Sheng Li, Li Lin, Jiagao Lv, Lintong Men, Dewei Peng, Lulu Peng, Bowen Ren, Wei Shi, Moran Wang, Tianshu Yang, Cuntai Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 332.34 Pawnshops
• Thông tin xuất bản: Australia : International journal of biological sciences , 2025
• Bộ sưu tập: NCBI
• ID: 746954

Tóm tắt

The macrophage-cardiomyocyte crosstalk as a potential intervention target for diabetic cardiomyopathy (DCM) remains deeper exploration. We found S100A9, as an immunoinflammatory mediator, was up-regulated in cardiomyocytes and macrophages in diabetic heart by single-cell analysis. Furthermore, F4/80