Cancer is a major contributor to global morbidity and mortality. Among the different forms of cancer, colorectal cancer (CRC) is the third most frequently diagnosed cancer in men and the second most common cancer type in women globally. We aimed to explore the possible synergistic anticancer potential of curcumin (Cur) and plumbagin (PL) in the human colon cancer cell line (HCT-116). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)/cytotoxicity assay revealed IC