Naples Prognostic Score (NPS) as a Novel Prognostic Score for Stage III Breast Cancer Patients: A Real-World Retrospective Study.

• Tác giả: Xiangyang Guo, Hongyan Jia, Xiaoqing Liu, Yongmin Miao, Wanfu Wang, Jun Yang, Rui Yang, Liang Yao, Bo Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 004.019 Psychological principles
• Thông tin xuất bản: New Zealand : Breast cancer (Dove Medical Press) , 2025
• Bộ sưu tập: NCBI
• ID: 747083
• Chủ đề: 1. Naples; 2. Prognostic; 3. Score

Tóm tắt

 OBJECTIVE: This study aims to explore whether Naples prognostic score (NPS) serves as a novel and original prognostic tool for predicting long-term survival in stage III breast cancer patients undergoing operation. METHODS: This retrospective study included 306 cases of stage III breast cancer patients hospitalized in our hospital from January 2014 to December 2018. In this study, NPS was based on five objective markers: (1) serum albumin level
  (2) total cholesterol
  (3) neutrophil to lymphocyte ratio
  (4) lymphocyte to monocyte ratio. Survival curves of DFS and OS differences were visualized by Kaplan-Meier method and Log rank test. The variables with p <
  0.05 in univariate analysis were performed in the multivariate Cox proportional hazard model analysis, and the p-values <
  0.05 was considered the underlying independent variables. Nomogram was constructed by the multivariate Cox proportional hazard model analysis. RESULTS: Significant variations for DFS and OS categorized according to prognostic risk for the different NPS (DFS: χ CONCLUSION: NPS serves as a predictive tool for assessing the prognosis of stage III breast cancer after surgery. Nomogram prognostic model based on NPS show good prediction ability.