BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a disease that emerged during the COVID-19 pandemic. Patients exhibit symptoms mimicking the clinical presentation of an acute abdomen, representing a novel differential diagnosis, particularly in the young generation. This study aims to investigate the current level of awareness of MIS-C among surgeons and medical students. METHODS: We conducted an anonymous online questionnaire among members of the Swiss Surgical Society and Swiss medical students. The questionnaires collected participants' baseline demographics and their awareness regarding MIS-C. RESULTS: Both students and surgeons obtained very low scores in the self-assessment and had a low score in the section with awareness questions (true score). In medical students, we observed a positive correlation between self-assessment and true scores ( CONCLUSION: The results show an insufficient level of awareness concerning MIS-C among students and surgeons, warranting implementation in students' curriculum and surgeons' continuous training.