The relevance of B7-H3 and tumor-associated macrophages in the tumor immune microenvironment of solid tumors: recent advances.

• Tác giả: Shuo Luan, Tingting Ren, Xiaodong Tang, Lu Xie, Jie Xu, Jiuhui Xu, Yiyang Yu, Yuwei Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 299.932 Gnosticism
• Thông tin xuất bản: United States : American journal of translational research , 2025
• Bộ sưu tập: NCBI
• ID: 747123

Tóm tắt

B7 homolog 3 (B7-H3) is a member of the B7 ligand family. It is highly expressed in various human cancers, especially mesenchymal malignancies. B7-H3 regulates cancer progression through multiple signaling pathways such as JAK2/STAT3, NF-κB, PI3K/AKT, and ERK. It also has the ability to downregulate CD8