Combining orbital intensity modulated radiation therapy with periorbital triamcinolone acetonide injection for Graves' orbitopathy.

• Tác giả: Wei-Min He, Huan Jian, Rui-Xin Ma
• Ngôn ngữ: eng
• Ký hiệu phân loại: 373.236 Lower level
• Thông tin xuất bản: China : International journal of ophthalmology , 2025
• Bộ sưu tập: NCBI
• ID: 747172

Tóm tắt

AIM: To evaluate the efficacy of combined orbital radiation and periorbital triamcinolone acetonide injection for patients with Graves' orbitopathy (GO) who experienced treatment failure with glucocorticoid pulse therapy (GPT). METHODS: A total of 57 eligible patients (35.09% males, mean age of 51.19±11.90y) were included in this case-series study. The medical information collected during each visit was evaluated and analyzed. RESULTS: Significant improvement was observed in patients six months after radiation therapy. Both the clinical activity score and the efficacy score showed substantial improvement ( CONCLUSION: The combination therapy demonstrates significant effectiveness in treating patients with GO who experienced severe ocular inflammation and have previous GPT failure. Noticeable improvement is observed as early as one month after initiating radiation therapy, and patients with more severe inflammatory states showes greater benefit from the treatment.