TBACN-Promoted Regioselective Cyanofunctionalization and Benzannulation: Enabling Access to Cyanoindolizine Scaffolds via Alkyne Cyclization.

• Tác giả: Karina S I Amudi, Sergen Gul, Burak Kuzu, Nurettin Menges
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.3482 Bibliographic analysis and control
• Thông tin xuất bản: United States : ACS omega , 2025
• Bộ sưu tập: NCBI
• ID: 747185

Tóm tắt

A novel and regioselective cyanofunctionalization-benzannulation cascade reaction has been developed, utilizing tetrabutylammonium cyanide (TBACN) as a practical and efficient cyanide source. This transformation provides streamlined access to a structurally diverse array of cyano-substituted indolizine scaffolds, which are valuable intermediates in the synthesis of nitrogen-containing heterocycles with potential pharmaceutical applications. The methodology employs readily available