Engineering a Biosynthetic Pathway to Produce (+)-Brevianamides A and B.

• Tác giả: Brian J Curtis, Samantha P Kelly, Sean A Newmister, Kaleb Ott, Filipa Pereira, Makayla Perez, Casandra P Sandoval Hurtado, Vikram Shende, David H Sherman
• Ngôn ngữ: eng
• Ký hiệu phân loại: 355.74 Engineering installations
• Thông tin xuất bản: United States : ACS catalysis , 2025
• Bộ sưu tập: NCBI
• ID: 747251
• Chủ đề: 1. Engineering; 2. A; 3. Biosynthetic

Tóm tắt

The privileged fused-ring structure comprising the bicyclo[2.2.2]diazaoctane (BDO) core is prevalent in diketopiperazine (DKP) natural products that exhibit potent and diverse biological activities. Typically, only low yields of these compounds can be extracted from native fungal producing strains and accessing them diastereoselectively remains challenging using available synthetic routes. BDO-containing DKPs including (+)-brevianamides A