BACKGROUND: Laparoscopic liver resection has a steep learning curve, and multiple difficulty-scoring systems have been proposed to support safe implementation. Though the IWATE scoring system is widely used, the rationale for its tumor location score is unclear. The objective of our study was to establish a more accurate definition of tumor location based on subsegments of the Glisson branches. METHODS: We included 176 patients who underwent laparoscopic liver resection between January 2017 and February 2024, excluding those who underwent multiple or concomitant resections of other organs. Tumor location was defined by the most proximal subsegment of the Glisson branches (1sp, Spiegel
1pc, para-caval
1cp, caudate process
3a, apical
3b, basal
4a
4b
5v, ventral
5d, dorsal
6v
6d
6 L, lateral
7v
7d
8v
8d). RESULTS: Within each segment, comparing operative time between subsegments showed significant differences, except for S1 (3a vs. 3b, CONCLUSIONS: There are significant differences in the difficulty of laparoscopic liver resection among subsegments. More detailed scoring based on subsegments may improve accuracy, and we propose a new scoring system.