Three timepoint perioperative CEA levels are a prognostic factor for recurrence after adjuvant chemotherapy in patients with Stage II and III colorectal cancer.

• Tác giả: Yoko Adachi, Hideo Baba, Ryosuke Hara, Hiroto Kikuchi, Yuko Kitagawa, Shimpei Matsui, Shodai Mizuno, Jumpei Nakadai, Koji Okabayashi, Kyoko Sakamoto, Ryo Seishima, Kohei Shigeta, Takehiro Shimada, Kiyoaki Sugiura, Hirofumi Suzumura
• Ngôn ngữ: eng
• Thông tin xuất bản: Japan : Annals of gastroenterological surgery , 2025
• Bộ sưu tập: NCBI
• ID: 747272

Tóm tắt

AIM: To investigate the relationship between the three timepoint perioperative CEA (ttpCEA) calculated at three timepoints and recurrence during the perioperative period in Stage II and III colorectal cancer (CRC) patients. METHODS: We performed a multi-institutional retrospective analysis of patients with Stage II and III CRC who underwent surgery and adjuvant chemotherapy from 2010 to 2020. Patient data from three facilities were used as training data, and data from three other facilities were used as validation data. The primary endpoint was the time to recurrence (TTR). RESULTS: A total of 538 patients were included for the training data. To validate the feasibility of ttpCEA, 329 patients were included for the validation data. Training data patients were categorized as ttpCEA low ( CONCLUSION: The ttpCEA calculated from perioperative CEA levels at different timepoints was a prognostic factor for recurrence in Stage II and III CRC patients who underwent adjuvant chemotherapy according to both the training and validation data.