Impact of gastrectomy on efficacy and safety of second-line chemotherapy patients with advanced gastric cancer: Exploratory analysis of two randomized phase III trials.

• Tác giả: Yusuke Akamaru, Kazumasa Fujitani, Hisashi Hosaka, Wasaburo Koizumi, Satoshi Morita, Kazuhiro Nishikawa, Ken Nishimura, Junichi Sakamoto, Ken Shimada, Motoko Suzuki, Akira Tsuburaya, Toshimasa Tsujinaka, Takaki Yoshikawa
• Ngôn ngữ: eng
• Ký hiệu phân loại: 373.236 Lower level
• Thông tin xuất bản: Japan : Annals of gastroenterological surgery , 2025
• Bộ sưu tập: NCBI
• ID: 747278

Tóm tắt

 AIMS: Second-line chemotherapy (SLC) improves survival in advanced gastric cancer (AGC). Although many patients receiving SLC have undergone gastrectomy, the impact of gastrectomy on SLC remains unclear. PATIENTS AND METHODS: The objective was to evaluate the impact of gastrectomy on SLC for AGC. A total of 290 eligible patients registered in two randomized phase III trials evaluating SLC for patients with AGC was classified into the prior gastrectomy group (PGG
  RESULTS: The PGG had better performance status ( CONCLUSION: Patients with previous gastrectomy are expected to have better survival outcomes when receiving second-line irinotecan (IRI)-based chemotherapy for AGC.