IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging.

• Tác giả: Daniel Brigger, Alexander Eggel, Stefan Forster, Carla A Jaeger-Ruckstuhl, Kai Kessenbrock, Inês Monteiro, Pascal Naef, Adrian F Ochsenbein, Carsten Riether, Noah Schnüriger
• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.3822 Electrical, magnetic, optical, communications, computer engineering; electronics, lighting
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 747316

Tóm tắt

Inflammatory cues affect hematopoietic stem cell (HSC) homeostasis and drive proliferation and myeloid skewing of HSCs. The HSC niche in the bone marrow (BM) is populated by a variety of stromal and immune cells that sense and respond to cellular stress. We investigated how BM-resident type 2 innate lymphoid cells (ILC2s) regulate HSC homeostasis and differentiation in steady state, during aging, and after genotoxic stress. We documented that PDGFR-α