BACKGROUND: Cervical epidural steroid injections (CESIs) are frequently utilized for the treatment of cervical radiculopathy and axial neck pain. Given the anatomical complexity of the cervical spine, techniques that enhance precision while maintaining safety are essential. This case series evaluates the safety of a catheter-based approach for CESI, allowing targeted medication delivery to the affected spinal level. METHODS: A retrospective review was conducted of 9 patients who underwent cervical ESIs using a catheter-based technique. Under fluoroscopic guidance, the epidural space was accessed with a touhy needle, and a flexible catheter was advanced to the level of pathology for medication administration. All patients were monitored during and after the procedure for any complications. RESULTS: All 9 procedures were successfully completed without any reported complications. There were no cases of dural puncture, neurological injury, or other adverse events associated with the procedure. CONCLUSION: This case series supports the safety and feasibility of catheter-based cervical epidural steroid injections. The technique allowed for accurate targeting of pathology without any observed complications. These preliminary findings warrant further investigation in larger, controlled studies to confirm safety and efficacy.