Platelet-to-Neutrophil Ratio: A Novel Prognostic Indicator for Anti-PD-1-Based Therapy in Relapsed/Refractory Hodgkin Lymphoma and Solid Tumors.

• Tác giả: Yixin Chang, Weidong Han, Yang Liu, Nannan Lu, Jing Nie, Yuting Pan, Xueting Qin, Chunmeng Wang, Xin Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 577.63158 +Aquatic ecology Freshwater ecology
• Thông tin xuất bản: China : MedComm , 2025
• Bộ sưu tập: NCBI
• ID: 747355

Tóm tắt

 Program cell death-1 (PD-1) blockade treatment has been shown effective in cases with relapsed/refractory classical Hodgkin Lymphoma (R/R cHL), while prognostic biomarkers remain unclear. Seventy-seven cases with R/R cHL who received immunotherapy for the first time were included. Receiver operator characteristic analysis displayed platelet-to-neutrophil ratio (PNR) as the most probable indicator among distinct inflammatory-cell ratios. Patients with high pretreatment PNR (≥ 51.6) achieved significantly higher complete response (CR) rate as compared with patients with low PNR (<
  51.6), and PNR