OBJECTIVE: To compare the effects between primary hepatic carcinoma (PHC) patients undergoing laparoscopic partial hepatectomy receiving Fast track surgery (FTS) nursing and traditional nursing, aiming to select an effective nursing intervention plan for such patients. METHODS: This study included 84 patients with PHC who underwent laparoscopic partial hepatectomy, randomly divided into an observation group (n42) and a control group (n=42). The observation group received FTS nursing, while the control group received traditional nursing care. Intraoperative and postoperative conditions, serological indicators, and complication rates were compared between the groups. RESULTS: The observation group showed significantly reduced postoperative drainage tube removal time, anal exhaust time, hospitalization expenses, and length of stay (LOS) compared to the control group (all P<
0.05). C-reactive protein (CRP), total bilirubin (Tbil), alanine aminotransferase (ALT), and cholinesterase (ChE) levels in the observation group were notably lower than those in the control group on postoperative days 1, 3, and 5 (all P<
0.05). No significant difference was found in postoperative complication rates between the observation (14.29%) and control groups (16.67%) ( CONCLUSIONS: Compared with traditional nursing, FTS nursing effectively reduces inflammation and liver function injury in patients undergoing PHC surgery, shortens LOS, lowers hospitalization expenses, and accelerates physical rehabilitation without increasing postoperative complications.