ITGA5 promotes cervical cancer progression by regulating IMP3 recruitment of HK2 mRNA.

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Tác giả: Shunyu Hou, Fan Hu, Yue Liu, Lu Shen, Yan Zhang, Liuxuanning Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 641.36 Meat

Thông tin xuất bản: United States : American journal of translational research , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 747400

 Cervical cancer is a prevalent gynecologic malignancy characterized by high rates of invasion and metastasis. Integrin alpha 5 (ITGA5), a member of the integrin family, has been implicated in tumor progression
  however, its regulatory role in cervical cancer remains poorly defined. Bioinformatic analyses revealed elevated ITGA5 expression in cervical cancer, which was further validated in patient tissues by immunohistochemistry (IHC). ITGA5 was either silenced or overexpressed in cervical cancer cell lines, and its effects on proliferation, invasion, and migration were assessed using CCK-8, Transwell, and wound healing assays. The
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