Single cell multiomics and 3D genome architecture reveal novel pathways of human heart failure.

• Tác giả: Justin Buchanan, Lei Chang, Neil C Chi, Jeffery Chiu, Sierra Corban, Agnieszka D'Antonio-Chronowska, Eugin Destici, Jovina Djulamsah, Stavros G Drakos, Ruth M Elgamal, Weston Elison, Elie N Farah, Kyle J Gaulton, Emily Griffin, Alyssa R Holman, Vincent Huang, Daofeng Li, Audrey Lie, Timothy Loe, Jacinta Lucero, Sainath Mamde, Rebecca Melton, Sutip Navankasattusas, Bing Ren, Craig H Selzman, Chanrung Seng, Thirupura S Shankar, Shaina Tran, Eleni Tseliou, Luca Tucciarone, Allen Wang, Ting Wang, Zhaoning Wang, Yang Xie, Qian Yang, Qingquan Zhang, Haowen Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.323 Dowsing
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 747513

Tóm tắt

 Heart failure is a leading cause of morbidity and mortality
  yet gene regulatory mechanisms driving cell type-specific pathologic responses remain undefined. Here, we present the cell type-resolved transcriptomes, chromatin accessibility, histone modifications and chromatin organization of 36 non-failing and failing human hearts profiled from 776,479 cells spanning all cardiac chambers. Integrative analyses revealed dynamic changes in cell type composition, gene regulatory programs and chromatin organization, which expanded the annotation of cardiac