Tranexamic Acid in Patients Undergoing Liver Resection: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

• Tác giả: Mohamed Abouzid, Husam Abu Suilik, Mohamed Abuelazm, Ahmed Almasry, Ibrar Atiq, Basma Badrawy Khalefa, AlMothana Manasrah, Wafaa Shehada, Mohammad Tanashat
• Ngôn ngữ: eng
• Ký hiệu phân loại: 793.2 Parties and entertainments
• Thông tin xuất bản: United States : Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis , 2025
• Bộ sưu tập: NCBI
• ID: 747880

Tóm tắt

 BackgroundTranexamic acid (TA), a synthetic lysine derivative, is known for its antifibrinolytic effect and potential to reduce bleeding in surgeries like arthroplasty, cardio-aortic procedures, and liver transplantation. This meta-analysis seeks to provide robust clinical evidence on TA's effectiveness in reducing blood loss and transfusion needs during orthotopic liver transplantation.MethodsThe systematic review and meta-analysis included the relevant randomized controlled trials (RCTs) retrieved from PubMed, EMBASE, Web of Science, Cochrane, and SCOPUS databases until August 2024. The meta-analysis was done using (RevMan 5.4.1). PROSPERO ID: CRD42024589151.ResultsOur meta-analysis of seven RCTs with 1875 patients found no significant differences between TA and control groups in total red blood cell units transfused (MD: -3.74 units
  95% CI [-8.49, 1.01]