Santorinicele is a cystic dilatation at the terminal end of the pancreatic duct of Santorini, which is a rare condition mostly associated with pancreatic divisum. Patients with Santorinicele may present with recurrent pancreatitis due to elevated intraductal pressure and outflow obstruction of pancreatic secretions. Different imaging modalities, including magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP), are useful tools in identifying the causes of recurrent pancreatitis, and other pancreatic pathology and anatomical variants. Here, we present a case of recurrent acute pancreatitis caused by pancreas divisum with Santorinicele and discuss the role of medical imaging in the diagnosis.