Yemen's escalating childhood leukemia crisis stems from war-induced environmental contamination and systemic healthcare collapse. Prolonged conflict has released toxic agents - including heavy metals and radioactive residues - into ecosystems, disproportionately harming children during critical developmental stages. Concurrent destruction of medical infrastructure has rendered nearly half of healthcare facilities non-functional, delaying diagnoses and restricting treatment access. Childhood leukemia cases reported by Yemen's Ministry of Health surged fivefold during the conflict, with 30% of cancer patients being children. However, these figures likely underestimate the crisis due to systemic underreporting from destroyed laboratories, displacement, and diagnostic barriers in inaccessible regions. This mirrors patterns in conflict zones like Fallujah (38-fold leukemia increase) and Gaza (heavy metal accumulation in infants). Unlike these regions, Yemen lacks foundational epidemiological tools - such as population-based cancer registries or genetic toxicity assays - to delineate leukemia clusters and their causes. Without such data, contamination mapping and accountability remain unattainable. Displacement and poverty exacerbate late-stage diagnoses and mortality. Urgent action must prioritize, investigating leukemia clusters through epidemiological methodologies and biomonitoring, mapping contamination sources
and rebuilding oncology infrastructure while halting military actions that perpetuate toxicity and deepen healthcare collapse. Yemen's children exemplify war's dual legacy: unstudied carcinogens and systemic healthcare abandonment, demanding accountability through global health ethics and intervention.