Rare ginsenosides, known for their significant pharmacological effects, are found in only trace amounts in natural ginseng, making it necessary to produce them through transformation processes. In this study, ginsenoside Re was chemically transformed into 30 rare ginsenosides using a novel heterogeneous catalyst HSiW@MeSi in aqueous methanol solution. The HSiW@MeSi catalyst was synthesized by the incorporation of silicotungstic acid (H