Mitochondrial Membrane Potential of CD8

• Tác giả: Shuling Chen, Jing Fan, Xiaoning Feng, Yuxiang Gong, Hongli Liu, Hao Ren, Lili Wang, Xixuan Wang, Qingfang Xiong, Yongfeng Yang, Changhua Yi, Wenquan Zeng, Caiyun Zhang, Hui Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of clinical and translational hepatology , 2025
• Bộ sưu tập: NCBI
• ID: 748179

Tóm tắt

BACKGROUND AND AIMS: Patients with cirrhosis are at an increased risk of bacterial infection (BI), which is the most common precondition for acute-on-chronic liver failure (ACLF). In this study, we aimed to evaluate the ability of mitochondria-related indicators (mitochondrial mass and mitochondrial membrane potential (MMP)) of T cells in peripheral blood to predict BI and ACLF within 90 days in cirrhotic patients. METHODS: We prospectively studied mitochondria-related indicators in various T cells from 235 cirrhotic patients at the Second Hospital of Nanjing. The outcomes of interest were BI and ACLF. RESULTS: The restricted cubic spline analysis showed that the MMP of CD8 CONCLUSIONS: The MMP of CD8