Single-cell RNA sequencing for characterizing the immune communication and iron metabolism roles in CD31

• Tác giả: Francesco Girolamo, Qi Guan, Yiming Guan, Meiyan Li, Yu Luan, Joshua D Palmer, Shanshan Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.323 Dowsing
• Thông tin xuất bản: China : Translational cancer research , 2025
• Bộ sưu tập: NCBI
• ID: 748283

Tóm tắt

BACKGROUND: Gliomas are aggressive brain tumors marked by complex cellular interactions and significant immune cell infiltration. This study investigated the role of CD31 METHODS: We employed the CellChat framework to map cell-cell communication pathways and used Monocle3 for pseudotime trajectory analysis to characterize the signaling and developmental progressions within CD31 RESULTS: Our findings highlight the expression of key pathways, including SPP1 and MHC-II, influencing immune regulation. Ferritin was found to be highly expressed in CD31 CONCLUSIONS: This study clarified the distinct roles of CD31