Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.

• Tác giả: Julián Balanta-Melo, Frank Beier, Courtney Brooks, Matthew W Grol, Geneva Herold, Jeffrey L Hutchinson, Rehanna Kanji, Patti Kiser, Brooke L O'Donnell, Silvia Penuela, Lilian I Plotkin, Cheryle A Séguin, Justin Tang, Brent Wakefield
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.891562 Diseases of nervous system and mental disorders
• Thông tin xuất bản: England : JBMR plus , 2025
• Bộ sưu tập: NCBI
• ID: 748298

Tóm tắt

Osteoarthritis (OA) is a multifactorial disease associated with aging. As the molecular mechanisms underpinning the pathogenesis of this disease are unclear, there are no disease-modifying drugs to combat OA. Pannexin 3 (PANX3) has been shown to promote cartilage loss during posttraumatic OA. In contrast, the ablation of