Hydrofluorocarbons (HFCs) are potent greenhouse gases whose global abundance continues to rise and subsequently warm the Earth. Southern China is a rapidly developing region that has experienced a sharp increase in its HFC consumption. Here, we present the first high-frequency HFC observations in Southern China from 2022 to 2023, analyzing the atmospheric mole fractions of four HFCs (HFC-134a, HFC-32, HFC-125, and HFC-143a) and using inverse modeling to estimate their emissions in Southern China. We find that HFC emissions in Southern China are primarily concentrated in Jiangsu, Zhejiang, and Guangdong, with Jiangsu having the highest HFC-134a emissions (4.1 ± 0.5 Gg yr