Mediating role of Interleukin-6 in the predictive association of diabetes with Hippocampus atrophy, Amyloid, Tau, and Neurofilament pathology at pre-clinical stages of diabetes-related cognitive impairment.

• Tác giả: Asma Hallab
• Ngôn ngữ: eng
• Ký hiệu phân loại: 003.5 Theory of communication and control
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 748413

Tóm tắt

INTRODUCTION: Type-2 diabetes (T METHODS: The study included a subset of 1,927 participants from the Health and Aging Brain Study: Healthy Disparities (HABS-HD) cohort with complete data. Cross-sectional and longitudinal analyses were performed. Associations were studied using multivariable linear, logistic, and mediation analysis with non-parametric bootstrapping. RESULTS: T CONCLUSIONS: The study captured a pre-clinical stage of the T