INTRODUCTION: Dandruff is a chronic scalp condition occurring in all hair types. Selenium disulfide (SeS METHODS: A 6-week study in adult subjects of any De La Mettrie hair type (I-VIII) assessed total dandruff, SD severity score (SSSD), erythema, hair greasiness, quality of life, discomfort, local tolerance, perceived benefit, acceptability, cosmeticity, and changes in the scalp microbiota. SeS RESULTS: Overall, 93 subjects of any hair type (women: 83%, hair types: I-III: 41%, IV-V: 29%, VI-VIII: 30%) were recruited. 69% were of European and 31% of African origin. SSSD and total dandruff scores were the highest in hair type IV-V, erythema scores in hair type I-III, and the itching score in hair type VI-VIII, with no differences between hair types for any parameter. After 4 weeks, clinical signs and subject assessments had significantly (all CONCLUSION: SeS