BACKGROUND AND OBJECTIVES: Chronic liver inflammation leads to fibrosis and cirrhosis. To avoid portal hypertension-related complications, fibrosis' early detection is imperative. Biopsy remains the gold standard, but magnetic resonance elastography (MRE) and EUS-guided elastography are noninvasive procedures currently used for liver stiffness measurement (LSM). Two-dimensional EUS-guided shear-wave elastography (EUS-SWE) represents a more-every-day used technique.The aim of this study is to correlate LSM determined by vibration-controlled transient elastography (VCTE) and EUS-SWE and determine the measurements' accuracy in diagnosing cirrhosis. METHODS: A single-center, nested case-control study was performed between March 2020 and November 2021. Patients were classified into 2 study groups: the cirrhosis group and the control group. Patients from both groups underwent VCTE and EUS-SWE for LSM. A RESULTS: Of the 59 participants included (mean age 63.5 years
71.1% female), 29 had cirrhosis (49.15%) and 30 were controls (50.84%). In cirrhosis patients, liver fibrosis (F) was staged as F3-4 by VCTE in 82.8%, with a median LSM of 17.8 kPa
through EUS-SWE, 27 kPa in the right hepatic lobe (RHL) and 25 kPa in the left hepatic lobe (LHL). Controls fibrosis was staged as F0-2 by VCTE in 30/30 (100%), with a median LSM of 4.6 kPa ( CONCLUSIONS: VCTE and EUS-SWE are comparable techniques for diagnosing cirrhosis
however, EUS-SWE had a higher agreement than VCTE, especially in LHL assessment.