The role of impaired iron transport on exercise performance and prognosis in patients with chronic heart failure.

• Tác giả: Piergiuseppe Agostoni, Marina Alimento, Anna Apostolo, Alice Bonomi, Jeness Campodonico, Giulia Grilli, Paola Gugliandolo, Massimo Mapelli, Irene Mattavelli, Beatrice Pezzuto, Arianna Piotti, Paolo Poggio, Valentina Rusconi, Elisabetta Salvioni, Carlo Vignati
• Ngôn ngữ: eng
• Ký hiệu phân loại: 354.33 Special forms of environmental protection and control
• Thông tin xuất bản: Ireland : International journal of cardiology. Heart & vasculature , 2025
• Bộ sưu tập: NCBI
• ID: 748576

Tóm tắt

 BACKGROUND: Iron deficiency (ID) is frequent in chronic heart failure (HF). Among HF-ID patients those with impaired iron transport (IIT) (Transferrin saturation (TSAT) <
  20 %) have the worst prognosis. In HF survival is strictly related to exercise limitation but the link between IIT, exercise limitation and survival is at present undefined. METHODS: We evaluated in 999 consecutive patients hospitalized for worsening HF whether IIT affects prognosis through cardiopulmonary exercise test (CPET), i.e. peak oxygen uptake (VO RESULTS: PeakVO CONCLUSIONS: The adverse impacts of low TSAT on prognosis are in part direct and in part mediated by mechanisms related to reduced peakVO