Characterizing the gut microbiota composition in Taiwanese hypertensive patients using 16S rRNA sequencing analysis.

• Tác giả: Jui-Chieh Chen, Ming-Shan Chen, Yan-Min Chen, Jou-Wei Chiang, Zhi-Yong Chong, Hsin-Yu Huang, Shin-Kuang Jiang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 343.0924 Military, defense, public property, public finance, tax, commerce (trade), industrial law
• Thông tin xuất bản: Australia : International journal of medical sciences , 2025
• Bộ sưu tập: NCBI
• ID: 748595

Tóm tắt

Hypertension (HTN) is a significant risk factor for cardiovascular and cerebrovascular diseases. Accumulating evidence suggests a close relationship between HTN and alterations in the gut microbiota composition and abundance. We recruited 23 HTN patients and 17 controls matched for demographic characteristics. DNA extracted from fecal samples of patients was subjected to Illumina MiSeq sequencing, targeting the V3-V4 region of the bacterial 16S rRNA gene for analysis. We compared the diversity and composition of gut microbiota between the two groups. The α-diversity of gut microbiota in HTN patients was similar to that in the control group. β-diversity analysis showed slight differences in microbial composition between the HTN and control groups. We used Welch's