This study is aimed at ascertaining the relationship between environmental risks of analgesics (acetaminophen, diclofenac, and ibuprofen), methylxanthine (caffeine), and antibiotics (amoxicillin, ciprofloxacin, and metronidazole) and physicochemical parameters (temperature, pH, electrical conductivity, salinity, total dissolved salts, and turbidity) of three replicates of untreated effluents from three hospitals (Kwame Nkrumah University of Science and Technology [KNUST] Hospital, Kumasi South Hospital [KSH], and Komfo Anokye Teaching Hospital [KATH]) within Kumasi, Ghana. The samples were filtered, extracted by solid phase, and analyzed by PerkinElmer Flexar HPLC. Samples showed ambient temperature, around neutral pH, and high electrical conductivity, salinity, total dissolved salts, and turbidity. Acetaminophen and diclofenac were detected at concentrations of 40.00-44.00 and 77.00-553.00