Comparative modelling of foetal exposure to maternal long-acting injectable versus oral daily antipsychotics.

• Tác giả: Shakir Atoyebi, Philip Bediako-Kakari, Mariella Monyo, Adeniyi Olagunju
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: England : npj women's health , 2025
• Bộ sưu tập: NCBI
• ID: 748981

Tóm tắt

This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of foetal exposure between oral and long-acting injectable (LAI) aripiprazole and olanzapine. Adult and pregnancy PBPK models were developed and validated with relevant clinical data. Relevant indices of foetal exposure during pregnancy were predicted from concentration-time data at steady-state dosing for both oral and LAI formulations. Foetal C