Analysis of whole-exome data of nonobese NAFLD patients from India reveals association with new markers on functionally relevant genes and pathways.

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Tác giả: Anamita Barik, Abhijit Chowdhury, Arnab Ghosh, Parha P Majumder, Rajesh K Rai, Jeffrey D Wall

Ngôn ngữ: eng

Ký hiệu phân loại: 633.14 *Rye

Thông tin xuất bản: India : Journal of genetics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 749293

Nonalcoholic fatty liver disease (NAFLD) occurs in a significant number of nonobese individuals, especially in Asian populations. Many genetic loci are associated with NAFLD. However, no exome-wide analysis of polymorphism data to identify asso- ciations with NAFLD is available for nonobese individuals from Asia. We have sought to fill this gap. With informed consent, we selected individuals from a defined population in India and assessed their liver fat-graded per international recommendations, and their demo- graphic and anthropometric data were collected. A set of 153 individuals were identified with high-grade liver fat. For each of these fatty- liver individuals (cases), two controls of the same sex with no or little liver fat were selected, the age and BMI of each control not exceeding 5 years and 5 kg/m
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