Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration.

• Tác giả: Xin Fu, Lili Han, Ping Hu, Sheng Li, Zhanghua Li, Xingzuan Lin, Xiexiang Shao, Jianhua Wang, Minghui Wang, Wenjun Yang, Hao Zhou, Shenao Zhou, Siyuan Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 020.683 Personnel management (Human resource management)
• Thông tin xuất bản: England : eLife , 2025
• Bộ sưu tập: NCBI
• ID: 749349

Tóm tắt

Tendon injury occurs at high frequency and is difficult to repair. Identification of human stem cells being able to regenerate tendon will greatly facilitate the development of regenerative medicine for tendon injury. Genetic and functional analyses identify human CD29+/CD56+ myogenic progenitors with tenogenic differentiation potential in vitro and in vivo. Transplantation of human CD29+/CD56+ myogenic progenitors contributes to injured tendon repair and thus improves locomotor function. Interestingly, the tendon differentiation potential in mouse muscle stem cells is minimal and the higher TGFβ signaling level may be the key for the distinct feature of human CD29+/CD56+ myogenic progenitors. The discovery of bi-potential CD29+/CD56+ myogenic progenitors highlights their potential as a novel adult stem cell source for tendon regeneration.