Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum.

• Tác giả: Hai-Yan Cao, Xiu-Lan Chen, Min Du, Fuchuan Li, Danrong Lu, Wenshuang Wang, Lin Wei, Xiangyu Xu, Yingying Xu, Qingdong Zhang, Yu-Zhong Zhang, Ruyi Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: England : eLife , 2025
• Bộ sưu tập: NCBI
• ID: 749375

Tóm tắt

Recently, a new class of glycosaminoglycan (GAG) lyases (GAGases) belonging to PL35 family has been discovered with an ultrabroad substrate spectrum that can degrade three types of uronic acid-containing GAGs (hyaluronic acid, chondroitin sulfate and heparan sulfate) or even alginate. In this study, the structures of GAGase II from