Noble metal nanozymes have attracted extensive attention in tumor therapy due to their multiple enzyme-like activities for catalytic therapy and unique optical properties for photothermal therapy (PTT). However, their therapeutic efficiency may be compromised by the intricate tumor microenvironment (TME). Herein, copper-platinum (CuPt) bimetallic nanozymes were synthesized and entrapped by poly(amidoamine) dendrimers, with