Design of Potent Small-Molecule Stimulator of Interferon Gene Inhibitor and Stimulator of Interferon Gene Mutant-Specific Degrader.

• Tác giả: Venkatesha Basrur, Miao He, Qiuxia Li, Zhongwei Liu, Hannah Myatt, Alexey Nesvizhskii, Farzad Sarkari, Duxin Sun, Jinsong Tao, Meilin Wang, Bo Wen, Luchen Zhang, Hong-Yi Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 573.378 *Small intestine
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 749458

Tóm tắt

Stimulator of interferon genes (STING) is involved in various autoimmune diseases. However, it is challenging to develop small-molecule STING inhibitors with potent activity. Herein, we designed a small-molecule STING inhibitor and STING mutant-specific degrader by binding two coupled pockets of a STING dimer. Structure optimization selected