MGF505-7R and I267L Deletions Attenuate African Swine Fever Virus and Confer Protection Against the Virulent Pandemic Virus in Pigs.

• Tác giả: Tao Feng, Dan Li, Huanan Liu, Zhao Ma, Xiaolan Qi, Jingjing Ren, Yi Ru, Chaochao Shen, Hong Tian, Sen Wu, Dongdong Zheng, Haixue Zheng, Linlin Zheng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: United States : FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 2025
• Bộ sưu tập: NCBI
• ID: 749472

Tóm tắt

African swine fever virus (ASFV) poses a serious risk to wild boars and domestic pigs worldwide. Developing live-attenuated vaccines (LAVs) containing specific gene deletions is an effective approach to prevent and control African swine fever (ASF) epidemics. We created a novel ASFV mutant, ASFV-GS-Δ7R/ΔI267L, with deletions of genes MGF505-7R and I267L, using the highly pathogenic parental strain ASFV-GS/2018 (ASFV-GS). In vitro, the viral titer of ASFV-GS-Δ7R/ΔI267L was approximately 10 times lower than that of its parental strain. Pigs inoculated with 10