Pattern of Deep Grey Matter Undersizing Boosts MRI-Based Diagnostic Classifiers in Fetal Alcohol Spectrum Disorders.

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Tác giả: Richard Delorme, Edouard Duchesnay, Monique Elmaleh-Berges, Justine Fraize, Pauline Garzón, David Germanaud, Lucie Hertz-Pannier, Eliot Kerdreux, Yann Leprince, Jean-François Mangin, Alexandra Ntorkou

Ngôn ngữ: eng

Ký hiệu phân loại: 726.59 Parts

Thông tin xuất bản: United States : Human brain mapping , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 749547

In fetal alcohol spectrum disorders (FASD), brain growth deficiency is a hallmark of subjects with both fetal alcohol syndrome (FAS) and nonsyndromic FASD (NS-FASD, that is, those without specific diagnostic features). Although previous studies have suggested that the deep grey matter is heterogeneously affected at the group level, it has not yet been established within proper scaling modeling, nor has it been given a place in the FASD diagnostic criteria where neuroanatomical features still contribute almost nothing to diagnostic specificity. We segmented a 1.5T T1-weighted brain MRI dataset of 90 monocentric FASD patients (53 FAS, 37 NS-FASD) and 95 typically developing controls (ages 6-20), using volBrain-vol2Brain as reference, and both Freesurfer-SAMSEG and FSL-FIRST to estimate result robustness. The segmentation resulted in seven anatomical volumes: total brain (TBV), total deep grey matter, caudate, putamen, globus pallidus, thalamus, and accumbens. After adjusting for confounds, we fitted the scaling relationship between deep grey matter nuclei volumes (V
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