Novel LC-MS/MS Method for Quantification of Famotidine and Metoprolol and Application to Pharmacokinetic Interaction.

• Tác giả: En-Fu Feng, Gong-Hao He, Rui Meng, Jian-Mei Pan, Ping Wang, Ran Xu, Sun-Jun Yin, Xue-Sha Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 540.11 Alchemy and systems
• Thông tin xuất bản: England : Biomedical chromatography : BMC , 2025
• Bộ sưu tập: NCBI
• ID: 749576

Tóm tắt

A rapid and sensitive LC-MS/MS method was developed and validated to simultaneously determine famotidine (FAM) and metoprolol (MET) in rat plasma and applied to study the pharmacokinetic drug-drug interaction between these two drugs in rats. In this method, D4-famotine (D4-FAM) and D6-metoprolol (D6-MET) were used as the internal standard and methanol protein precipitation method was used for sample preparation. After extraction, the samples were carried on an Agilent Gemini-NX C